Extended Data Fig. 4: Bazedoxifene suppresses ferroptosis in mammalian cells.
From: A compendium of kinetic modulatory profiles identifies ferroptosis regulators
a, Cell death quantified as the number of SYTOX Green positive (SG+) objects (that is dead cells) over time. Data are from two independent experiments. b,c, Cell death quantified by SG+ object counting. Data are from three or four independent experiments. d, Outline of the STY-BODIPY kinetic competition assay. Egg-phosphatidylcholine (1 mM) and STY-BODIPY (10 µM) are incubated with 0.2 mM di-tert-undecyl hyponitrite (DTUN), in addition to a radical trapping antioxidant (RTA-H).
