Extended Data Fig. 6: Effect of pH on the hovlinc ribozyme activity.
From: Hovlinc is a recently evolved class of ribozyme found in human lncRNA

a−j, The cleavage reactions incubated for the indicated length of time either in the presence of 6 mM Mg2+ or EDTA at the indicated pH were resolved on the denaturing PAGE gels. k, The raw kobs values (in addition to Fig. 2c which plots log kobs values) at different pH. The activity was either negligible or undetectable at pH 6 and 5 respectively. Conditions of pH >10 could not be tested due to RNA degradation.