Extended Data Fig. 7: Effect of different cations on the hovlinc ribozyme activity.
From: Hovlinc is a recently evolved class of ribozyme found in human lncRNA

a, b, d−f, The cleavage reactions incubated for the indicated length of time either in the presence of the indicated cations: Mn2+ (a), Ca2+ (b), Co2+ (d), Co(NH3)63+ (e), Li+ (f) or EDTA at the indicated pH were resolved on the denaturing PAGE gels. c, Time courses of cleavage reactions performed in the presence of various divalent cations at pH 8. Y-axes show the fraction of cleaved products (Ft) for each time point (X-axes). Each symbol represents average Ft from two replicates, and lines represent fitted curves.