Extended Data Fig. 8: Integration of sbABP technology with other technologies available to study proteolytic networks.
From: Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
Conceptual workflow indicating how sbABP technology (a cleavage-centric approach) could be integrated with substrate-centric and protease-centric approaches to identify proteolytic mediators and develop inhibitors/ABPs to control a particular proteolytic event. TAILS, Terminal amine isotopic labeling of substrates; COFRADIC, Combined fractional diagonal chromatography; sbABP, substrate-biased activity-based probe.
