Extended Data Fig. 8: mTORC1-selective bi-steric inhibitors suppress S6 phosphorylation in tumors and inhibit tumor growth in MCF-7 xenografts.
From: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
a, Levels of pS6 S240/S244 as percent of control determined for lysates from MCF-7 tumors at end of study over a period of 72 hours following the final dose of a repeat dosing schedule. Data are the mean signal of each group (n = 3) and error bars represent SD. b, Mean tumor volume of MCF-7 xenografts following daily oral administration (po qd) of MLN0128, and once weekly intraperitoneal (ip qw) administration of bi-steric inhibitors (n = 12 animals per group), with error bars representing SEM. c, Percent tumor volume change of individual MCF-7 xenografts with daily oral administration (po qd) of MLN0128, and once weekly intraperitoneal (ip qw) administration of bi-steric inhibitors. Gray zone represents 10% margin of error for tumor growth and shrinkage. Similar results for each agent were observed in at least n = 2 independent experiments.
