Extended Data Fig. 4: Evoracle performance on ABE8e evolution replicates.
From: Reconstruction of evolving gene variants and fitness from short sequencing reads
Model evaluation on replicate PACE experiments 1 and 3 of the ABE8e directed evolution campaign. Samples 1-20 are from low-stringency PANCE, samples 21-29 are from high- stringency PANCE, and samples 30-36 are from PACE. a, Observed frequencies of 34 mutations. Colors represent amino acid mutations, using the same coloring scheme as in Fig. 2a-b. b, Observed full-length genotype trajectories. Colors represent full-length genotypes, using the same coloring scheme as in Fig. 2c-d. c, Inferred full-length genotype trajectories. Colors represent full-length genotypes, using the same coloring scheme as in Fig. 2c-d. d, Consistency between observed and predicted full-length genotype frequencies; scatter plot and swarm plot with kernel density estimate.
