Extended Data Fig. 8: Standard Chow did not affect OmeY absorption.
From: Genetic-code-expanded cell-based therapy for treating diabetes in mice
a, Schematic diagram of the NATS-mediated rapid insulin response to feeding on ncAA ‘cookies;’. Mice were implanted with microencapsulated engineered cells harboring the NATS system. Through intake of ncAA ‘cookies’, mice absorb ncAAs, which trigger a fast insulin response based on translational activation. b, Photos of homemade ncAA ‘cookies’ for feeding the T1DM mice. c, Pharmacokinetic analysis of serum OmeY concentrations in mice after oral gavage (o.g.) administration. Each point represents the mean ± SEM from 5 mice. Two-way ANOVA. d, Treatment schedules for long-term therapies in T1DM by OmeY oral gavage or ncAA ‘cookies’.
