Extended Data Fig. 1: POI expression mediated by the NATS system composed of aaRS/tRNA pair.
From: Genetic-code-expanded cell-based therapy for treating diabetes in mice
a, The chemical structure of OmeY and BocK and used in this study. b, Exploring the impact of amber codon position on the expression of a POI (SEAP) in HEK293T cells. MbPylRS/tRNAPyl pair was used for BocK incorporation. SEAP levels in culture supernatants were measured 48 h after stimulation with BocK. The signal-to-noise ratio is indicated above the bars. Data are presented as the mean ± SD; n = 3 independent samples.
