Extended Data Fig. 6: Comparison of the two receptor protomers in the asymmetric conformation against previously reported structures.
From: Symmetric and asymmetric receptor conformation continuum induced by a new insulin
Left, Vh-Ins:IR asymmetric state apolike protomer (blue) vs apo IR (PDBs 4ZXB). Right, the second Vh-Ins:IR protomer (pink) vs insulin-bound receptor (6PXV) following alignment on L1, CR, L2, and FnIII-1 domains.
