Extended Data Fig. 5: Sensitivity of patient-derived organoids to JQ1.
From: Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer
a, Response of normal and cancer organoids to JQ1. Representative images from three technical replicates with similar results. Scale bar, 500 μm. b, Response of organoids derived from tubular adenoma and serrated lesion to JQ1. Representative images from three technical replicates with similar results. Scale bar, 500 μm. c, Response of genetically engineered normal organoids with single (APC) and quadruple (APC, KRAS, TP53 and SMAD4) mutations to JQ1. Representative images from three technical replicates with similar results. Scale bar, 500 μm.
