Extended Data Fig. 4: Modular recording of diverse biological signals.
From: Scalable biological signal recording in mammalian cells using Cas12a base editors
a, Schematic showing modular recording by incorporating different inducible promoters into the guide construct. b, Cellular memory of NFAT signaling, stimulated by PMA. c, Cellular memory of oxidative stress, stimulated by tBHQ. ROS = reactive oxygen species. All experiments in b-c shown in GFP* HEK cells stably transduced with respective inducible guide, for 3 independent replicates 3 days post transfection with base editor.
