Extended Data Fig. 6: Superposition of CcTet-6mA-dsDNA (cyan/wheat) with FTO-6mA-ssDNA (green/purple, pdb code: 5ZMD) complexes.
From: A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA
(a) Superposition of 6 mA in CcTet active pocket and 6 mA (purple) in FTO (green) active pocket. The wheat region indicates the key FTO residue that was reported to play key roles in m6A catalysis. (b) LC-MS/MS analysis of 6 mA demethylation by CcTet mutations. N = 3 biologically independent experiments. Data represent mean values ± s.d.
