Extended Data Fig. 1: Effect of different analogues of CID661578 on β-cell regeneration.
From: MNK2 deficiency potentiates β-cell regeneration via translational regulation
a, Chemical structures of the different analogues of CID661578 synthesized for the screen. b, Quantification of the number of regenerating β-cells in Tg(ins:kaede);Tg(ins:CFP-NTR) treated with the indicated analogue, tested in three different concentrations from 4-6 dpf after β-cell ablation. The absence of bars denote that the chemical treatment was toxic to the larvae. n = 32 (DMSO), n = 1 (CID661578-100 µM), n = 13 (CID661578-30 µM), n = 15 (CID661578-10 µM), n = 0 (CID661578.2-100 µM), n = 14 (CID661578.2-30 µM), n = 16 (CID661578.2-10 µM), n = 0 (CID661578.3-100 µM), n = 16 (CID661578.3-30 µM), n = 16 (CID661578.3-10 µM), n = 0 (CID661578.4-100 µM), n = 13 (CID661578.4-30 µM), n = 16 (CID661578.4-10 µM), n = 16 (CID661578.5-100 µM), n = 14 (CID661578.5-30 µM), n = 16 (CID661578.5-10 µM), n = 16 (CID661578.6-100 µM), n = 16 (CID661578.6-30 µM), n = 16 (CID661578.6-10 µM), n = 0 (CID661578.7-100 µM), n = 16 (CID661578.7-30 µM), n = 16 (CID661578.7-10 µM), n = 14 (CID661578.8-100 µM), n = 14 (CID661578.8-30 µM), n = 15 (CID661578.8-10 µM), n = 8 (CID661578.9-100 µM), n = 12 (CID661578.9-30 µM) and n = 16 (CID661578.9-10 µM). Data are presented as mean values ±SEM.
