Fig. 4: The effect of oligomeric state of helix-hairpin peptides on virus neutralization.
From: A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein
a, Sedimentation-velocity analytical ultracentrifugation data of selected helix-hairpin peptides. OS, oligomeric state. b, Dose-dependent effect of the peptides in pseudovirus neutralization assay with hACE2-overexpressing HEK293T cells. The data represent the average and standard deviation of replicates (n = 2). All pseudoviral assays were repeated three times. c, Kinetics of the pseudoviral infection in the presence of LCB1 and SIH-5. SIH-5 displayed significant enhancement in virus neutralization from 0 to 30 min preincubation compared to LCB1. The data represent the average and standard deviation of replicates (n = 2). All pseudoviral assays were repeated three times. d, DLS intensity distribution for pseudovirus (control) and pseudovirus incubated with LCB1, SIH-5 and SIH-11. A single representative intensity distribution out of three independent DLS measurements for each condition is provided.
