Extended Data Fig. 4: Multiple sequence alignment of SN243 with characterized bacterial GH3 family members. | Nature Chemical Biology

Extended Data Fig. 4: Multiple sequence alignment of SN243 with characterized bacterial GH3 family members.

From: Functional metagenomic screening identifies an unexpected β-glucuronidase

Extended Data Fig. 4

For this alignment the closest 33 sequences (accession codes indicated) from the phylogenetic tree generated with ClustalW were selected and aligned, and displayed with ESPript (http://espript.ibcp.fr/ESPript/cgi-bin/ESPript.cgi). Conservation is highlighted in black. A consensus marked by arrows identifies the catalytic nucleophile Asp415 (a) and the acid-base dyad Asp331/His333 (b).

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