Extended Data Fig. 9: Comparison of ligand binding pocket between DHEA-ADGRG2-FL and Cortisol-ADGRG3.
From: Structures of the ADGRG2–Gs complex in apo and ligand-bound forms
a, Comparison of ligand binding pocket between DHEA-ADGRG2-FL and Cortisol-ADGRG3 (PDB: 7D77). Compared with Cortisol, the DHEA has a 30˚ tilting toward TM5-TM6. The angles for DHEA-ADGRG2-FL TM6-TM7 kinks were labeled by two-way arrows in red. b, Structural representation of three conserved large hydrophobic residues forming direct contacts with ligands shared by both DHEA-ADGRG2-FL and Cortisol-ADGRG3. c, Sequence alignment of conserved pocket residues involved in ligand recognition in DHEA-coupled ADGRG2-FL and Cortisol-bound ADGRG3.
