Extended Data Fig. 5: Apolipoprotein E (ApoE) binds the LDL receptor to mediate nanoparticle uptake in the absence of apolipoprotein B (ApoB).
From: Identifying cell receptors for the nanoparticle protein corona using genome screens
a, Uptake of ApoE coated gold nanoparticles in unedited, LACZ knockout and LDL receptor knockout cells. Mean ± std are reported from 3 independent replicates. b, Quantification of ApoE coated gold nanoparticle uptake with ApoE at 100-fold molar excess of ligands to nanoparticles. Data is normalized to uptake without competitor ligands. Mean ± std are reported from 3 independent replicates. P-values are indicated and calculated using an unpaired two-tailed t-test. c, Abundance of ApoB and ApoE in the C57BL/6 J mouse protein corona compared to human protein corona determined by mass spectrometry.
