Extended Data Fig. 5: TRPV2 inhibition by cholesterol derivatives.
From: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands
a, Chemical structures of cholesterol and its derivatives dexamethasone (DEX), chorionic corticotropin (CCT) and human chorionic thyrotropin (HCT). b, representative whole-cell recording of TRPV2 current activated by 2-APB is inhibited by DEX, HCT or CCT at 30 µM. c, Percentage of TRPV2 current inhibition by 30 μM HCT, DEX, and CCT (n = 6 cells). Data were presented as mean ± s.e.m.
