Extended Data Fig. 8: TRPV2 mutants with abolished 2-APB activation are still functional.
From: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands
a to d, Representative current activation by 2 mM probenecid in the mutant Y466A, Q525N, L620A and L627T, respectively, where 2-APB (2 mM) activation is virtually abolished. The protein of these mutants is expressed on the cell membrane as shown in confocal imaging. n = 3 independent experiments. e, Magnitude of current activation by probenecid (2 mM) in TRPV2 mutants (n = 3-4 cells). Data were presented as mean ± s.e.m.
