Extended Data Fig. 9: The 2-APB binding site.
From: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands
a to c, 3D reconstruction maps of mTRPV2E2_2-APB, 2-APB bounded inactivated state of rat TRPV2 (7N0M), and 2-APB bounded activated state of rat TRPV2 (7NON). Dashed circles in red or purple indicates the binding site of 2-APB observed in our study or in rat TRPV2 (7N0M or 7NON), respectively. d, Comparison of the atomic models of our mTRPV2CHL and rat TRPV2 (5HI9) in the apo state.
