Extended Data Fig. 4: MD simulations of cholesterol binding in mTRPV2Q525F and mTRPV2Q525T_LMNG.
From: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands
a, RMSD of Q525F is also plotted against simulation time in three independent all-atom MD trajectories. b, RMSD of Q525T is also plotted against simulation time in three independent all-atom MD trajectories. c, Cholesterol inside the VBP of mTRPV2Q525T_LMNG. The residues close to cholesterol and employed to measure their distance to cholesterol are shown. d, The probability distribution of distance between cholesterol and VBP residues (measured at center of mass in Y466, L470, L477, S498 and L502).
