Fig. 1: Conservation of the SARS-CoV-2 spike protein.
From: Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors
a, Sequence conservation from 44 related spike proteins overlaid on the SARS-CoV-2 spike protein structure (left) and the SARS-CoV-2 RBD (right; residues 319–541) (PDB ID: 6VXX) identifies a highly conserved patch in S2. Color gradient is a step gradient of conservation containing nine total steps of sequence conservation identified from the ConSurf database; gradient is shown on the bottom. b, Sequence identity for all residues in the SARS-CoV-2 spike protein compared to a set of 44 related coronavirus spike proteins shows higher conservation in the S2 relative to the S1. A value of 1.0 means perfect identity across all compared coronavirus proteins. RBD and NTD domains of SARS-CoV-2 spike are labeled on the top; S1 and S2 domains are labeled on the bottom.
