A combined structural and biochemical analysis reveals that TRIM7 E3 ligase targets viral proteins for degradation by recognizing their C-terminal glutamine (C-Gln) via its PRY-SPRY domain, providing mechanistic insight into the C-degron pathway.
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Guo, Q., Chen, X. & Xu, C. TRIM-away via Gln/C-degrons. Nat Chem Biol 18, 1168–1169 (2022). https://doi.org/10.1038/s41589-022-01164-7
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DOI: https://doi.org/10.1038/s41589-022-01164-7
