Fig. 2: The structure of PSMD2 reveals a new ligand binding site.
From: Targeted degradation via direct 26S proteasome recruitment
a, Structure of PSMD2 in complex with two Fabs and macrocycle MC1. Macrocycle MC1 (orange) binds between C-terminal and solenoid domains of PSMD2 (teal). PSMD2-interacting Fab chaperones are shown in gray. b, Ribbon diagram of PSMD2 (teal) with MC1 shown as orange sticks; CTD, C-terminal domain; NTD, N-terminal domain. c, Close-up of the binding site shows residues HRYxGW of macrocycle MC1 interact with K773, L873, E336, H868, E878, V846, H770 and N737 on PSMD2.
