Fig. 3: The macrocycle epitope is positioned close to the AAA+ unfoldase of the 26S proteasome, making it ideal for target delivery. | Nature Chemical Biology

Fig. 3: The macrocycle epitope is positioned close to the AAA+ unfoldase of the 26S proteasome, making it ideal for target delivery.

From: Targeted degradation via direct 26S proteasome recruitment

Fig. 3

a, Overlay of the PSMD2–MC1 structure with the 26S proteasome structure 6MSJ. b, Zoom-in of the binding site shows that MC1 binds PSMD2 near the proteasomal unfoldase and is well positioned for substrate delivery.

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