Extended Data Fig. 3: SIRT1 depletion sensitizes cells to CPT.
From: SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition
MDA-MB-231 cells infected with lentiviruses expressing control or SIRT1 shRNAs were treated with indicated doses of CPT. Cells were then shifted to fresh medium and permitted to grow for an additional 14 days before staining. Results shown are means of three independent experiments and were presented as means ± SEM. P-values were determined by two-way ANOVA.
