Extended Data Fig. 7: Analogs of FINO2 redistribute throughout the cell.
From: Identification of essential sites of lipid peroxidation in ferroptosis
a. Structures of analogs of FINO2. b. Confocal fluorescence images of HT-1080 cells treated with FINO2-5 (3 µM) or FINO2-6 (3 µM) and fer-1 (3 µM), and co-stained with LysoTracker Red. c. Dose-response curves of HT-1080 cells treated with fixed concentrations of FINO2 analogs (10 µM) and varying concentrations of ferroptosis inhibitors. Lysosome-directed ferrostatin previously published by Gaschler et al.27. Data are represented as mean ± SEM, n=3. d. Confocal fluorescence image of HT-1080 cells treated with FINO2-7 (3 µM) and fer-1 (3 µM). e. Dose-response curves of HT-1080 cells comparing treatment with FINO2-1 and FINO2-3 or FINO2-4. Data are represented as mean ± SEM, n=3.
