Extended Data Fig. 10: Comparison of H3K36-bound enzyme structures.

a, Structures of H3K36 lysine demethylase KDM2A, b, H3K36 lysine methyltransferase Set2 (PDB:6NZO) and c, H3K36 lysine methyltransferase NSD3 (PDB:7CRR) bound to the nucleosome. d, Sequence alignment of KDM2A and KDM2B JmjC-adjacent sequences, with acidic amino acids colored red.