Extended Data Fig. 4: BT4193 confers resistance to deoxycholic acid and polymyxin B.
From: Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron
a, Growth of B. thetaiotaomicron strains during deoxycholic acid treatment, and quantification of area under the growth curve normalized to untreated bacteria. The ∆BT4193 ∆BT3254 strain exhibited decreased fitness in the presence of deoxycholic acid (mean ± SEM; 16 independent replicates). Statistical significance was determined using a one-way ANOVA test with post hoc Dunnett’s multiple comparisons tests compared with wild type (p = 0.0002; WT-∆BT4193, p = 0.14; WT-∆BT3254, p = 0.42; WT-∆BT4193 ∆BT3254, p < 0.0001; WT-∆BT4193::BT4193WT, p = 0.45; WT-∆BT4193::BT4193S606A, p = 0.72; ****P < 0.0001). b, Growth of B. thetaiotaomicron strains during polymyxin B treatment.
