Extended Data Fig. 6: NicA2 wildtype has solvent exposed channels.
From: Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme
a, The crystal structure of wildtype NicA2 (PDB 5TTJ) is rendered with the solvent accessible surface area. The arrow marks a solvent exposed channel into the active site of NicA2. b, A different view of wildtype NicA2. The arrow marks a cavity on the surface of the protein that approaches the active site.
