Extended Data Fig. 4: Comparison of the small molecule components of VHL PROTAC ternary complex structures.
From: DNA-encoded library-enabled discovery of proximity-inducing small molecules
(a) Overlaying the VHL binding moieties of ternary complex assemblies, the diverse projection vectors of the connectors and target protein ligands are shown. The initial point of divergence for the bifunctional molecules is the carbon atom following the terminal amide of the VH032 ligand. (b) Comparison of the buried surface area for four VHL-targeting CIPs.
