Extended Data Fig. 7: Cycloheximide binding to the E site sterically clashes with A76 of a deacylated tRNA bound to the E site.
From: Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1
(a-b) Cryo-EM densities of cycloheximide (a) and the CCA-end (b) and their corresponding atomic models are shown in the 60S environment. (c) Superimposition of the two models, showing the steric clash of cycloheximide with tRNA.
