Extended Data Fig. 6: Additional data from two-week rat toxicology study with FeM-1269.
From: Minimizing higher-order aggregation maximizes iron mobilization by small molecules
a, Animal weights from two-week daily administration of FeM-1269 at 30, 100 and 300 mg/kg/day in male rats (n = 3 animals per group). b, Animal weights from two-week daily administration of FeM-1269 at 30, 100 and 300 mg/kg/day in female rats (n = 3 animals per group). c, Pharmacokinetic study of serum concentrations of FeM-1269 on day 1 of the study in male rats (n = 2 animals per group). d, Pharmacokinetic study of serum concentrations of FeM-1269 on day 15 of the study in males (n = 2 animals per group). e, Pharmacokinetic study of serum concentrations of FeM-1269 on day 1 of the study in females (n = 2 animals per group). f, Pharmacokinetic study of serum concentrations of FeM-1269 on day 15 of the study in females (n = 2 animals per group). g, Calculated pharmacokinetic parameters from studies in c–f. Error bars indicate SEM.
