Extended Data Fig. 9: Additional data from anemia of inflammation study in Fig. 6.
From: Minimizing higher-order aggregation maximizes iron mobilization by small molecules
In a–f, mice were treated as described in the supporting information section ‘Anemia of Inflammation Dose-Escalation Study’ (n = 10 animals for Sham and TO + bleed groups; n = 12 for all other groups). a, Weight of mice employed in the study. b, Calculated daily exposure to FeM-1269 based on pharmacokinetic data in Extended Data Fig. 4i. c, Transferrin saturation following daily administrations of hinokitiol (predicted area under the curve (AUC) 9560 ng/mL * hr). d, Total serum iron following daily administration of hinokitiol. e, Hemoglobin following daily administration of hinokitiol. f, Hematocrit following daily administration of hinokitiol. Sham and vehicle data in c–f are replicated from Fig. 6. Statistics were analyzed in Prism using one-way ANOVA with Dunnett’s or Tukey’s multiple comparisons tests as appropriate. For p-values, please see the source data file. Error bars indicate SEM. Where displayed, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 relative to vehicle controls or as otherwise specified.
