Extended Data Fig. 3: Physicochemical parameters and chemical structures of highly effective iron mobilizers.
From: Minimizing higher-order aggregation maximizes iron mobilization by small molecules
a–f, Physicochemical parameters of top tropolones in each assay for iron mobilization (n = 20 tropolones). Extracted from the datasets displayed in Extended Data Fig. 2. g, Chemical structures of the top 20 tropolone iron mobilizers in shDMT1-Caco-2 epithelia at 10 μΜ are largely substituted with short alkyl- or alkoxy-side chain substituents. Of note, (+)-6 and (−)-6 are isolated during the preparation of (±)-6 and were independently evaluated. See the Supplementary Note for details on chiral separation. Error bars indicate SEM.
