Extended Data Fig. 4: MTHFD2-mediated metabolic alteration modulates GC B-cell formation and responses.
From: Metabolic determinants of germinal center B cell formation and responses
a,b, Levels of the indicated metabolites in B cells treated as in Fig. 3a. Cells per group from n = 3 mice. c, Levels of the indicated metabolites in activated B cells treated with or without DS44. Cells per group from n = 3 mice. d, 13C-glutathione abundance in naive B cells activated for the indicated time points in medium containing 13C3-serine. Cells per group from n = 3 mice. e, ROS levels in each cell type from spleens of NP-KLH-immunized mice (n = 3 per group). All data are the mean ± SEM.; Two-tailed Student’s t-test (c-e); ns, not significant.
