Extended Data Fig. 1: Developing small molecules for BMAL1.
From: Pharmacological targeting of BMAL1 modulates circadian and immune pathways
a, Structure of hit01 (Left). Melting curve of BMAL1(PASB) with DMSO or hit01 (Middle). Shift of BMAL1(PASB) Tm value with DMSO, hit01 or CCM at various concentration (Right). b, Affinity of compounds to BMAL1(PASB) measured by surface plasmon resonance (SPR). c, Affinity fitting of SPR data at equilibrium points for binding of CCM to BMAL1(PASB) protein.
