Extended Data Fig. 4: Selectivity of CCM for BMAL1.
From: Pharmacological targeting of BMAL1 modulates circadian and immune pathways
a, Sequence alignments of ARNT, ARNT2, BMAL1 and BMAL2. The sequence identity of PASBs to BMAL1(PASB) 338–441 are 38.5% (ARNT), 38.5% (ARNT2) and 70.2% (BMAL2). b, Structural basis for lack of CCM binding to related PASBs. Protein structures used here are extracted from PDB 2KDK (BMAL2), 4ZP4 (ARNT) and 7XI3 (ARNT2).
