Extended Data Fig. 7: Z218484536 inhibits epileptic spikes in a cynomolgus monkey model of TLE.
From: Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures
(a) Experimental design. The control group consisted of Control-1 (female, 3.7 kg, 7 years old), Control-2 (male, 6.5 kg, 6 years old), and Control-3 (male, 6.9 kg, 7 years old); the Z218484536 group consisted of Z218484536-1 (female, 3.6 kg, 7 years old), Z218484536-2 (6.1 kg, 10 years old), and Z218484536-3 (male, 7.7 kg, 9 years old). (b) Representative 1-min EEG tracings showing EEG activity before and after administration of vehicle or Z218484536. (c) Spike frequencies at baseline (yellow background, 3 EEG recordings) and during treatment with vehicle and Z218484536 (green background, 4 EEG recordings). (d, e) Statistical comparisons of spike frequencies among baseline and time points 1 and 4 after treatment with vehicle (d) or Z218484536 (e). (f) The plasma concentration of Z218484536 in monkeys 1 h after treatment. Data were obtained for the three Z218484536-treated monkeys. The data are shown as the means with individual points. Statistical analyses were performed via two-tailed paired t test (d, e).
