SAMBA, a new chemically induced proximity system, overcomes the cost, complexity and reversibility challenges of such systems by precisely controlling protein interactions in a biocompatible manner mediated by salicylic acid, with applications in reprogramming oscillations, calcium signaling, receptor tyrosine kinase activation and cancer immunotherapy.
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Zhou, Y., Ma, X. & Ye, H. A SAMBA for chemically induced proximity. Nat Chem Biol 21, 1310–1311 (2025). https://doi.org/10.1038/s41589-025-01934-z
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DOI: https://doi.org/10.1038/s41589-025-01934-z
