Extended Data Fig. 1: Positions of PtdIns(4,5)P2-binding sites.
From: Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P2 binding
(a) Structure of βarr1 in complex with NTSR1 and one PtdIns(4,5)P2 molecule in a detergent micelle (PDB ID: 6UP7). (b) Sequence alignments of the C domain from the human βarr1 and βarr2. Positive charge residues are shown in red, negative charge residues in magenta, hydrophobic residues in blue, polar residues in green, aromatic residues in cyan, cysteines in pink, glycines in orange, proline in yellow, and non-conserved residues in white. The red arrow points to the NC site, and the blue arrow points to the C site.
