Engineering non-natural functions into enzymes has opened unexpected avenues for chemical synthesis. Whereas past efforts in repurposing natural enzymes have predominantly focused on heme- and flavin-dependent enzymes, latest work further highlights the advantages and potential of non-heme iron enzymes for organic synthesis.
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McLachlan, J., Hammer, S.C. Non-heme iron enzymes step into the spotlight. Nat Chem Biol 21, 1650–1651 (2025). https://doi.org/10.1038/s41589-025-02004-0
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DOI: https://doi.org/10.1038/s41589-025-02004-0
