Engineering non-natural functions into enzymes has opened unexpected avenues for chemical synthesis. Whereas past efforts in repurposing natural enzymes have predominantly focused on heme- and flavin-dependent enzymes, latest work further highlights the advantages and potential of non-heme iron enzymes for organic synthesis.
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References
Jain, S., Ospina, F. & Hammer, S. C. JACS Au 4, 2068–2080 (2024).
Buller, R. et al. Science 382, eadh8615 (2023).
Zhao, L.-P. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-01953-w (2025).
Zhou, K. Z. Q. & Obexer, R. Isr. J. Chem. 64, e202400006 (2024).
Ye, C. X., Dansby, D. R., Chen, S. & Meggers, E. Nat. Synth. 2, 645–652 (2023).
Zhao, L.-P. et al. Nat. Synth. 3, 967–975 (2024).
Rui, J. et al. Science 376, 869–874 (2022).
Zhao, Q. et al. Nat. Synth. 3, 958–966 (2024).
Seffernick, J. L., de Souza, M. L., Sadowsky, M. J. & Wackett, L. P. J. Bacteriol. 183, 2405–2410 (2001).
Tsutsumi, H. et al. J. Am. Chem. Soc. 140, 6631–6639 (2018).
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McLachlan, J., Hammer, S.C. Non-heme iron enzymes step into the spotlight. Nat Chem Biol (2025). https://doi.org/10.1038/s41589-025-02004-0
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DOI: https://doi.org/10.1038/s41589-025-02004-0