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Chemical glycobiology

Sweet spots of O-glucosylation

Nature Chemical Biology (2025)Cite this article

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Chemical biology tools are critical to provide new insights into glycobiology. A protein O-glycosyltransferase, Legionella translocated protein M (LtpM), is reported as a glycoengineering tool that requires strict and short consensus sequons to probe β-O-glucosylation and O-GlcNAcylation.

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Fig. 1: Identification and application of strict consensus sequons of protein β-O-glucosylation catalyzed by LtpM.

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Acknowledgements

The authors are partially supported by National Institutes of Health/National Cancer Institute grant P30 CA051008 and the Mizutani Foundation for Glycoscience.

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  1. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA

    Junfeng Ma & Chunyan Hou

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  1. Junfeng Ma
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  2. Chunyan Hou
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Correspondence to Junfeng Ma.

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The authors declare no competing interests.

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Ma, J., Hou, C. Sweet spots of O-glucosylation. Nat Chem Biol (2025). https://doi.org/10.1038/s41589-025-02007-x

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