Extended Data Fig. 7: Toxicity evaluation on DAA.
From: A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy
a, Body weight of mice from different treatment groups (n = 7 mice per group). Data are shown as mean ± s.d. b,c, Mice bearing HCC827 xenografts treated with vehicle or with DAA (5 or 10 mg/kg i.p. five times per week). After 27 days, mice were sacrificed and organs were removed. Representative photographs b and H&E images c were shown. Scale bars, 100 μm. n = 3 independent experiments. d, Clinical signs of KM mice in acute toxicity analysis of DAA (n = 4 mice per group). e, Toxicology analysis of complete blood count, differential, and blood chemistry in KM mice treated with vehicle, or with DAA (10 mg/kg i.p. once per day for two weeks, n = 5 mice per group).
