Extended Data Fig. 6: Stability and degradation analysis of NEtrapHTL@LNP in vivo.
From: Designing chemigenetic DNA nanotrap for norepinephrine dynamic imaging in organelles
a, Schematic diagram of NEtrapHTL@LNP. b, TEM image of NEtrapHTL@LNP. c, Confocal image of NEtrapHTL@LNP collected from fluorescence signal between 520-650 nm. Three independent experiments yielded similar results. d, FT-IR spectra of (I) NEtrapHTL, (II) LNP, (III) Xen2174 and (IV) NEtrapHTL@LNP. e, Confocal fluorescence images of brain slices: (I) overview of brain slices; (II) DAPI signal (nuclear marker); (III) probe signal; (IV) DBH signal (NE neuron marker); (V) merged image. Three independent experiments yielded similar results. f, Fluorescence images of LC region in brain slices at different time points after NEtrapHTL@LNP was injected into the LC region of mice. Three independent experiments yielded similar results. g, Quantitative analysis of fluorescence imaging intensity in (f). Data are presented as mean ± S.D. Error bars: S.D., n = 3 independent experiments. h, Fluorescence images of various organs at different time points after NEtrapHTL@LNP was injected into the LC region of mice. Three independent experiments yielded similar results.
