Supplementary Figure 4.: Mouse β2M does not efficiently form stable MHC class I complexes with human HLA α-chains | Nature Immunology

Supplementary Figure 4.: Mouse β2M does not efficiently form stable MHC class I complexes with human HLA α-chains

From: Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Supplementary Figure 4.

FACS histogram of parental DLD1 cells (black), DLD1 cells reconstituted with a human β2M transgene (red), or with a mouse β2M transgene (blue). While fully human β2M expression facilitates robust surface MHC class I expression, as detected by the pan-HLA antibody W6/32, expression of mouse β2M facilitates only low levels of surface MHC class I.

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