Supplementary Figure 20: Genetic relatedness and structure in the Milieu Intérieur cohort. | Nature Immunology

Supplementary Figure 20: Genetic relatedness and structure in the Milieu Intérieur cohort.

From: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Supplementary Figure 20

(a) Genetic relatedness in the Milieu Intérieur cohort. Pairs of related subjects were detected using an estimate of the kinship coefficient and the proportion of SNPs that are not identical-by-state between all possible pairs of subjects, using KING. (b) Genetic structure of the Milieu Intérieur cohort. Genetic structure was estimated with the Principal Component Analysis (PCA) implemented in EIGENSTRAT. For comparison purposes, the analysis was performed on 261,827 independent SNPs and 1,723 individuals, which include the 1,000 Milieu Intérieur subjects together with 723 individuals from a selection of 36 populations of North Africa, the Near East, western and northern Europe (Online Methods).

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