Supplementary Figure 23: Local association signals detected by multi-trait GWAS of immunophenotypes measured in the Milieu Intérieur cohort. | Nature Immunology

Supplementary Figure 23: Local association signals detected by multi-trait GWAS of immunophenotypes measured in the Milieu Intérieur cohort.

From: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Supplementary Figure 23

(a) Local association signals at loci influencing principal components of a PCA of all innate cell immunophenotypes. No suggestive signal (P<5x10-8) was observed for PCs of a PCA of adaptive cell immunophenotypes. (b) Local association signal with the absolute numbers of HLA-DR+ TCM, TEM and TEMRA cells, either CD4+ or CD8+. The six corresponding immunophenotypes were analyzed altogether using a multivariate GWAS (Online Methods).

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