Supplementary Figure 1: Apoe–/– recipients of BXD2 bone marrow did not exhibit augmented autoantibody production without HFD.
From: Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27
(a-b) Bone marrow chimeric mice were generated as described in Fig. 1 and were subjected to normal chow (NC). (a) ELISA of autoantibodies against dsDNA, and histone in the sera. (b) ELISA of autoreactive IgG subclass autoantibodies against dsDNA. (c) Gating strategy used for flow cytometry analysis of each cell types. (d-g) Representative flow cytometry data of germinal center B (d), plasma (e), TFH cells (f), and TFR (g) cells in the spleens of the bone marrow chimeric mice depicted in Fig. 2b,c. Data are one representative experiment of four independent experiments with n=5 per group.
