Supplementary Figure 1: Relative gene expression of cAMP-controlled genes in SKCM and COAD biopsies. | Nature Immunology

Supplementary Figure 1: Relative gene expression of cAMP-controlled genes in SKCM and COAD biopsies.

From: Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

Supplementary Figure 1

(a) Relative expression of genes that are regulated by cAMP-mediated signaling in primary melanoma (SKCM, n = 104) and colon carcinoma (COAD, n = 285) biopsies. Expression of mRNAs encoding ICER is shown (CREM). (b) Overview of the Crem gene. The green boxes denote exons of Crem and Icer. The red box (Icer-specific exon) highlights the exon that is exclusively part of Icer but not of Crem. ****P ≤ 0.0001, two-tailed, unpaired t test with Welch’s correction.

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